Corticosteroids, vitamin D3 analogs, and calcineurin inhibitors, which are used to treat psoriasis, have diverse adverse effects, whereas natural products are popular due to their high efficiency and relatively low toxicity.
Psoriasis is a chronic inflammatory skin disease accompanied by excessive keratinocyte proliferation. Presented results indicated that MLT-containing products in combination with Vitamin C dosage are worth to be considered as a preventive alternative in the therapy of various diseases in the etiopathogenesis, of which radical and inflammatory mechanisms play an important role.
This observation confirms that MLT-containing samples affect the intracellular production of enzymes and neutralize the free radicals. The presence of PHT-MLT (12.5, 25 and 50 µg/mL) and vitamin C (12.5, 25 and 50 µg/mL) in the H 2O 2-pretreated HaCaT keratinocytes protected the cells from generating reactive oxygen species. However, the antioxidant studies on HaCaT keratinocytes stimulated with H 2O 2 revealed a noticeable activity in all samples. The antiradical properties of PHT-MLT determined in the DPPH test (IC 50 of 21.6 ± 1 mg of powder/mL) were found to originate from the presence of other metabolites in the 50% EtOH extract while SNT-MLT was found to be inactive under the applied testing conditions. Higher antiradical potential and COX-2 inhibitory properties of PHT-MLT could be explained by the presence of additional naturally occurring constituents in alfalfa, chlorella, and rice, which were clearly visible on the HPLC-ESI-QTOF-MS fingerprint. 6.5 times stronger than that of SNT-MLT (43.3% and 6.7% enzyme inhibition, equivalent to the activity of acetylsalicylic acid in conc.
COX-2 inhibitory activity of PHT-MLT was found to be ca. For this purpose, a COX-2 enzyme inhibitory activity test, an antiradical activity in vitro and on cell lines assays, was performed on both PHT-MLT and SNT-MLT products. This work aims to assess the recently established anti-inflammatory and antioxidant potential of melatonin of plant origin extracted from the plant matrix as a phytomelatonin complex (PHT-MLT), and compare its activity with synthetic melatonin (SNT-MLT) when used on its own or with vitamin C. Such a robust spectral behaviour of induced defect modes is unique, and, to our knowledge, is not observed in similar CLC-based structures.
Furthermore, our simulations based on a Berreman 4 × 4 matrix approach for a wide range of CLC thickness show both periodic and continuous generation of defect modes along particular spectral lines inside the PBG. We show that multimode laser generation is possible due to the observed multiple defect modes in the PBG that enlarges the application range of the system. In this paper, we investigate the lasing possibilities of a dye-doped polymer layer embedded in a wedge-shaped CLC. In particular, many studies have been devoted to the spectral control of the defect modes depending on their thickness, optical properties, distribution along the CLC, etc. In this context, the investigation of optical properties of induced defect modes in such CLCs is of great interest.
To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.Ĭholesteric liquid crystals (CLCs) with induced defects are one of the most prominent materials to realize compact, low-threshold and tunable coherent light sources.
Issues are regarded as officially published after their release is announced to the table of contents alert mailing list.Our present work reports a new engineering tactic to obtain heterogeneous and multifunctional electrocatalysts that achieve this goal. Scientists are looking for a cost-effective solution to this. This idea, though innovative, is unfortunately hampered by the challenge of slow kinetics and selectivity because continuous seawater electrolysis (due to limited access to freshwater) may trigger chloride ion oxidation into undesired species of chlorine and/or hypochlorite. A current goal is utilizing intermittent electricity from renewable sources (wind, solar, etc.) to decompose water molecules (H 2O) into green hydrogen (H 2), known as the “fuel of future” and pure oxygen (O 2), and use them in a reverse process to electrify our planet without any carbon dioxide pollution : 2H 2O = 2H 2 + O 2.